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rahimi, V., farahani, S., Saeidpour, A., Jalaie, S., Mahdi, P. (2014). Effects of Fish Oil Supplementation during the Suckling Period on Auditory Neural Conduction in n-3 Fatty Acid-Deficient Rat Pups. Iranian Journal of Otorhinolaryngology, 26(3), 135-141. doi: 10.22038/ijorl.2014.2756
vida rahimi; saeid farahani; Atoosa Saeidpour; Shohre Jalaie; Parvane Mahdi. "Effects of Fish Oil Supplementation during the Suckling Period on Auditory Neural Conduction in n-3 Fatty Acid-Deficient Rat Pups". Iranian Journal of Otorhinolaryngology, 26, 3, 2014, 135-141. doi: 10.22038/ijorl.2014.2756
rahimi, V., farahani, S., Saeidpour, A., Jalaie, S., Mahdi, P. (2014). 'Effects of Fish Oil Supplementation during the Suckling Period on Auditory Neural Conduction in n-3 Fatty Acid-Deficient Rat Pups', Iranian Journal of Otorhinolaryngology, 26(3), pp. 135-141. doi: 10.22038/ijorl.2014.2756
rahimi, V., farahani, S., Saeidpour, A., Jalaie, S., Mahdi, P. Effects of Fish Oil Supplementation during the Suckling Period on Auditory Neural Conduction in n-3 Fatty Acid-Deficient Rat Pups. Iranian Journal of Otorhinolaryngology, 2014; 26(3): 135-141. doi: 10.22038/ijorl.2014.2756

Effects of Fish Oil Supplementation during the Suckling Period on Auditory Neural Conduction in n-3 Fatty Acid-Deficient Rat Pups

Article 2, Volume 26, Issue 3, July and August 2014, Page 135-141  XML PDF (248 K)
Document Type: Original
DOI: 10.22038/ijorl.2014.2756
Authors
vida rahimi1; saeid farahani 1; Atoosa Saeidpour2; Shohre Jalaie3; Parvane Mahdi1
1Department of Audiology , School of Rehabilitation, Tehran University of Medical Science, Tehran, Iran.
2Department of Nutrition, School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3Department of Statistics, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
Abstract
Introduction: Omega 3 fatty acid especially in the form of fish oil, has structural and biological role in the body's various systems especially nervous system. Numerous studies have tried to research about it. Auditory is one of the affected systems. Omega 3 deficiency can have devastating effects on the nervous system and auditory. This study aimed to evaluate neural conduction in n-3 fatty acid-deficient rat pups following the supplementation of fish oil consumption during the suckling period
Materials and Methods: In this interventional and experimental study, one sources of omega3 fatty acid (fish oil) were fed to rat pups of n-3 PUFA-deficient dams to compare changes in their auditory neural conduction with that of control and n-3 PUFA-deficient groups, using Auditory Brainstem Response (ABR). The parameters of interest were P1, P3, P4 absolute latency, P1-P3, P1-P4 and P3-P4 IPL , P4/P1 amplitude ratio . The rat pups were given oral fish oil, 5 Ml /g weight for 17 days, between the age of 5 and 21 days.
Results There were no significant group differences in P1 and P3 absolute latency (p > 0.05). but the result in P4 was significant(P ≤ 0.05) . The n-3 PUFA deficient +vehicle had the most prolonged (the worst) P1-P4 IPL and P3-P4 IPL compared with control and n-3 PUFA deficient + FO groups. There was no significant difference in P1-P4 IPL and P3-P4 IPL between n-3 PUFA deficient + FO and control groups (p > 0.05).There was a significant effect of diet on P1-P4 IPL and P3-P4 IPL between groups (P ≤ 0.05).
Conclusion: The results of present study showed the effect of omega3 deficiency on auditory neural structure during pregnancy and lactation period. Additionally, we observed the reduced devastating effects on neural conduction in n-3 fatty acid-deficient rat pups following the supplementation of fish oil during the suckling period
Keywords
Auditory Brainstem Response; Fish oil; n-3 Fatty Acid Deficiency; Rat pups
Main Subjects
Pediatric
References

1. Das UN. Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J. 2006; 1(4):420–39.

2. Bourre JM. Where to find omega-3 fatty acids and how feeding animals with diet enriched in omega-3 fatty acids to increase nutritional value of derived products for human: what is actually useful ? J. Nutr Health Aging.2005; 9(4):232–42.

3. Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids.Biomed Pharmacother. 2002; 56(8):365–79.

4. Church MW, Jen K-LC, Stafferton T, Hotra JW, Adams BR. Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother. Neurotoxicol Teratol . 2007; 29:203–10.

5.Crawford MA, Golfetto I, Ghebremeskel K. The potential role for arachidonic and docosahexaenoic acids in protection against some central nervous system injuries in preterm infants. Lipids. 2003; 38 (4): 303–15.

6. Haubner L, Sullivan J, Ashmeade T, Saste M. The effects of maternal dietary docosahexaenoic acid intake on rat pup myelin and the auditory startle response. Dev  Neurosci. 2007; 29(6):460–67.

 7. Church MW, Jen KL, Jackson DA, Adams BR, Hotra JW. Abnormal neurological responses in young adult offspring caused by excess omega-3 fatty acid (fish oil) consumption by the mother during pregnancy and lactation. Neurotoxicol Teratol.2009;31:26–33.

8. Gopinath B, Flood VM, Rochtchina E. Consumption of omega-3 fatty acids and fish and risk of age-related hearing loss. Am J Clin Nutr. 2010; 92(2):416–21.

9. Moriguchi T, Loewke J. Garrison M. Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. J Lipid Res. 2001;42:       419–28.

10. Kimura F. Ito Sh. Endo Y. Supplementation of DHA-Rich Microalgal Oil or Fish Oil During the Suckling Period in Mildly n-3 Fatty Acid-Deficient Rat Pups. Lipids. 2011; 46(12):1101–10.

11. Church MW, Jen K-LC, Stafferton T, Hotra JW, Adams BR. Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother. Neurotoxicol Teratol. 2007;29: 203–10.

12. Shahnaz Pourarian,Bijan Khademi, Narjes Pishva, Ali Jamali .Prevalence of Hearing Loss in Newborns Admitted to Neonatal Intensive Care Unit. Iran J Otorhinolaryngol. 2012; 24(68):                129–134.

13. G.T. Rossi, Britt R.H. Effects of hypothermia on the cat brain-stem auditory evoked response. Electroencephalogr Clin Neurophysiol. 1984; 57 (2): 143–55.

14. Church MW, Blakley BW, Burgio DL,  Gupta AK. WR-2721 (Amifostine) ameliorates  cisplatin- induced hearing loss but causes neurotoxicity in

hamsters: dose-dependent effects. J Assoc Res Otolaryngol. 2004; 5(3):227–37.

15. Henry KR. Auditory brainstem volume-conducted responses: origins in the laboratory mouse. J Am Aud Soc. 1979; 4(5):173–8.

16. Church MW, Jen K-L.C, Anumba J.I. Excess omega-3 fatty acid consumption by mothers during pregnancy and lactation caused shorter life span and abnormal ABRs in old adult offspring. neurotoxicology and Teratology.2010;32: 171–81.

17. Church MW, Jen KL, Dowhan LM, Adams BR, Hotra JW. Excess and deficient omega-3 fatty acid during pregnancy and lactation cause impaired neural transmission in rat pups. Neurotoxicol Teratol. 2008;30:107–17.

18. La Presa O.S. and Innis S.M. Diverse, region-specific effects of addition ofarachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. Pediatr. Res.2000;48: 125–30.

19. Bourre JM, Durand G, Erre JP, Aran JM. Changes in auditory brainstem responses in alpha-linolenic acid deficiency as a function of age in rats. Audiology.1999; 38:13–18.

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