The comparison between effect of chemoradiation with weekly cisplatin with or without celecoxib in treatment of nasopharyngeal carcinoma:
A phase III clinical trial
Introduction: Concurrent cisplatin-based chemoradiation is currently considered the treatment of choice for locoregional nasopharyngeal carcinoma. Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor which can potentially enhance the effect of radiotherapy. The aim of this study was to determine the efficacy and safety of celecoxib in nasopharyngeal carcinoma.
Materials and Methods: Patients with newly diagnosed locoregional nasopharyngeal carcinoma were included in this clinical trial study. The patients were assigned to receive 7 weeks concurrent chemoradiation with weekly cisplatin and either celecoxib 100 mg twice daily or placebo. After completion of chemoradiation, all patients received combined chemotherapy with cisplatin plus 5-Fu every 3 weeks for 3 cycles. Clinical response rates and treatment-related toxicity were the primary and secondary end-point of the study.
Results: Total of 50 eligible patients with the median age of 43 years were enrolled in the trial. Overall (complete and partial) clinical response rate was 100% in both groups. Complete and partial clinical response rates were 64% and 36% in study group and 44% and 56% in control group respectively (P>0.25). There was no difference in terms of treatment-related toxicity rates between two groups.
Conclusions: This clinical trial showed that addition of celecoxib 100 mg twice daily to concurrent chemoradiation does not increase the response rates and treatment-related toxicities in patients with locoregional nasopharyngeal carcinoma.
Mohammadianpanah, M., Razmjoo Ghalaee, S., Khademi, B., Shafizadeh, A., Omidvari, S., Mosallaei, A., Ahmadloo, N., & Ansari, M. (2009). The comparison between effect of chemoradiation with weekly cisplatin with or without celecoxib in treatment of nasopharyngeal carcinoma:
A phase III clinical trial. Iranian Journal of Otorhinolaryngology, 21(56), 55-62. doi: 10.22038/ijorl.2009.437
MLA
Mohamad Mohammadianpanah; Sasan Razmjoo Ghalaee; Bijan Khademi; Amin Shafizadeh; Shapour Omidvari; Ahmad Mosallaei; Niloufar Ahmadloo; Mansour Ansari. "The comparison between effect of chemoradiation with weekly cisplatin with or without celecoxib in treatment of nasopharyngeal carcinoma:
A phase III clinical trial". Iranian Journal of Otorhinolaryngology, 21, 56, 2009, 55-62. doi: 10.22038/ijorl.2009.437
HARVARD
Mohammadianpanah, M., Razmjoo Ghalaee, S., Khademi, B., Shafizadeh, A., Omidvari, S., Mosallaei, A., Ahmadloo, N., Ansari, M. (2009). 'The comparison between effect of chemoradiation with weekly cisplatin with or without celecoxib in treatment of nasopharyngeal carcinoma:
A phase III clinical trial', Iranian Journal of Otorhinolaryngology, 21(56), pp. 55-62. doi: 10.22038/ijorl.2009.437
VANCOUVER
Mohammadianpanah, M., Razmjoo Ghalaee, S., Khademi, B., Shafizadeh, A., Omidvari, S., Mosallaei, A., Ahmadloo, N., Ansari, M. The comparison between effect of chemoradiation with weekly cisplatin with or without celecoxib in treatment of nasopharyngeal carcinoma:
A phase III clinical trial. Iranian Journal of Otorhinolaryngology, 2009; 21(56): 55-62. doi: 10.22038/ijorl.2009.437
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