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Iranian Journal of Otorhinolaryngology
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Mahmoudi, H., Baradaranfar, M., Behniafard, N., Dadgarnia, M., Atighechi, S., Zand, V., Baradaranfar, A., Vaziribozorg, S. (2017). The Effect of Topical Tranexamic Acid on Bleeding Reduction during Functional Endoscopic Sinus Surgery. Iranian Journal of Otorhinolaryngology, 29(2), 69-74. doi: 10.22038/ijorl.2017.19344.1652
Hossein Mahmoudi; Mohammad Hossein Baradaranfar; Nasim Behniafard; Mohammad Hossein Dadgarnia; Saeid Atighechi; Vahid Zand; Amin Baradaranfar; Sedighe Vaziribozorg. "The Effect of Topical Tranexamic Acid on Bleeding Reduction during Functional Endoscopic Sinus Surgery". Iranian Journal of Otorhinolaryngology, 29, 2, 2017, 69-74. doi: 10.22038/ijorl.2017.19344.1652
Mahmoudi, H., Baradaranfar, M., Behniafard, N., Dadgarnia, M., Atighechi, S., Zand, V., Baradaranfar, A., Vaziribozorg, S. (2017). 'The Effect of Topical Tranexamic Acid on Bleeding Reduction during Functional Endoscopic Sinus Surgery', Iranian Journal of Otorhinolaryngology, 29(2), pp. 69-74. doi: 10.22038/ijorl.2017.19344.1652
Mahmoudi, H., Baradaranfar, M., Behniafard, N., Dadgarnia, M., Atighechi, S., Zand, V., Baradaranfar, A., Vaziribozorg, S. The Effect of Topical Tranexamic Acid on Bleeding Reduction during Functional Endoscopic Sinus Surgery. Iranian Journal of Otorhinolaryngology, 2017; 29(2): 69-74. doi: 10.22038/ijorl.2017.19344.1652

The Effect of Topical Tranexamic Acid on Bleeding Reduction during Functional Endoscopic Sinus Surgery

Article 2, Volume 29, Issue 2, March and April 2017, Page 69-74  XML PDF (491 K)
Document Type: Original
DOI: 10.22038/ijorl.2017.19344.1652
Authors
Hossein Mahmoudi 1; Mohammad Hossein Baradaranfar1; Nasim Behniafard1; Mohammad Hossein Dadgarnia1; Saeid Atighechi1; Vahid Zand1; Amin Baradaranfar2; Sedighe Vaziribozorg1
1Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Medical Student, Iran University of Medical Sciences, Tehran, Iran
Abstract
Introduction:
Bleeding is a common concern during functional endoscopic sinus surgery (FESS) that can increase the risk of damage to adjacent vital elements by reducing the surgeon’s field of view. This study aimed to explore the efficacy of topical tranexamic acid in reducing intraoperative bleeding.
 Materials and Methods:
This double-blind, randomized clinical trial was conducted in 60 patients with chronic rhinosinusitis with polyposis (CRSwP) who underwent FESS. Patients were randomly divided into two groups; tranexamic or salinetreatment. During surgery, normal saline (400 mL) or tranexamic acid (2 g) in normal saline with a total volume of 400 mL were used in the saline and tranexamic groups, respectively, for irrigation and suctioning. The surgeons’ assessment of field of view during surgery and intraoperative blood loss were recorded.
 Results:
Mean blood loss was 254.13 mL in the saline group and 235.6 mL in the tranexamic group (P=0.31). No statistically significant differences between the two groups were found in terms of other investigated variables, such as surgical field quality based on Boezzart’s scale (P=0.30), surgeon satisfaction based on a Likert scale (P=0.54), or duration of surgery (P=0.22).
 Conclusion:
Use of tranexamic acid (2 g in 400 mL normal saline) through washing of the nasal mucosa during FESS did not significantly reduce blood loss or improve the surgical field of view. Further studies with larger sample sizes and higher drug concentrations, and using other methods of administration, such as spraying or applying pledgets soaked in tranexamic acid, are recommended.
Keywords
Bleeding; Rhinosinusitis; Polyposis; Tranexamic Acid; Topical; Sinus; Surgery
Main Subjects
Rhinoplasty; Surgery
References
 

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