Otitis Media with Effusion in Children and the Impact of Risk Factors on Serum Cytokine Levels

Document Type: Original


1 Department of Allergy and Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran.

2 ENT and Head and Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences,Tehran,Iran.

3 ENT and Head and Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences,Tehran,Iran.

4 Department of Health, Epidemiologist, Mississippi State, United States.

5 Department of Radiology, University of Mississippi Medical Center, Mississippi State, United States.


To evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (OME)
 Materials and Methods:
We investigated serum levels of interleukins (IL)-4, IL-5, and IL-13, along with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), by enzyme-linked immunosorbent assay (ELISA) in 35 children with OME and 28 healthy controls.
Children with OME had significantly higher levels of IL-5 in comparison with the control group, ranging from 1 pg/ml in cases to 0.04 pg/ml in controls (P=0.009). However, after adjusting for confounding variables, there was no significant difference in serum levels of IL-13, IL-4, IFN-γ, or TNF-α between the two groups (P=0.287, P=0.627, P=0.793, and P=0.217, respectively)
The findings of this study suggest that in comparison with the control group, serum IL-5 levels were elevated in OME cases.


Main Subjects

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