Head and Neck Lymphoma in an Iranian Population

Document Type: Original

Authors

1 Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

3 Dental Student, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Department of Oral and Maxillofacial Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Introduction:
This study is aimed to assess the prevalence and characteristics of head and neck lymphoma in a defined group of an Iranian population.
 
Materials and Methods:
In this retrospective study, 126,450 biopsy reports from two referral Pathology Departments, (Tehran, the capital of Iran) were evaluated. In cases with head and neck lymphoma, other variables such as age, sex, specific location of lesions, and histopathological findings were recorded. Descriptive statistics were used to measure the prevalence and characteristics of head and neck lymphoma by means of SPSS soft ware, version 18.
 
Results:
In total, 513 (0.4%) cases had head and neck lymphoma (46.9% male, 27.1% female) with a mean age of 46±6.2. Of the total lesions, 200 (0.15%) were Hodgkin lymphoma and 313 (0.25%) were non-Hodgkin lymphoma. Nodular sclerosis was the most common (62.5%) histopathological subtype among Hodgkin lymphoma. In non-Hodgkin lymphoma, diffuse large B-cell lymphoma (62.3%) had the highest frequency.  In Hodgkin disease, classic Hodgkin lymphocytic rich, mixed cellularity, and lymphocyte depletion were only seen in the neck compartment. Bone involvement was only found in Hodgkin nodular lymphocytic predominant variation. In non-Hodgkin lymphoma, the tongue, palate, and vestibular mucosa were affected only by diffuse large B-cell lymphoma. Jaw bones were only involved with diffuse large B-cell lymphoma compared to other bony structures. T-cell lymphoma and mucosal associated lymphoid tissue lymphoma were also found.
 
Conclusion:
Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma especially in the tongue, palate, vestibular mucosa, and jaw bones.

Keywords

Main Subjects


1. Larizadeh MH, Damghani MA, Shabani M. Epidemiological characteristics of head and neck cancers in southeast of Iran. Iran J Cancer Prev. 2014; 7(2):80-6.

2. Ajayi OF, Adeyemo WL, Ladeinde AL, Ogunlewe M.O, Effiom O.A, Omitola O.G, et al. Primary malignant neoplasms of orofacial origin: a retrospective review of 256 cases in a Nigerian tertiary hospital. Int J Oral Maxillofac Surg. 2007; 36(5):403-8.

3. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin's lymphoma: a 20-year demographic study of 381 cases. Int J Oral Maxillofac Surg. 2010; 39(9):  869-72.

4. Akbari ME, Bastani Z, Mokhtari S, Atarbashi Moghadam S. Oral Lymphoma Prevalence in Iranian Population: A Multicenter Retrospective Study. Iran J Cancer Prev. 2015;8(6):e4124.

5. Mohtasham N, Babakoohi S, Sarraf-Yazdy M, Sadr B, Ghaffarzadegan K, Shiva A,  et al. Oral and jaw lymphoma in an Iranian population. J Craniofac Surg. 2011;22(3):868-70.

6. Andisheh Tadbir A1, Mehrabani D, Heydari ST. Primary malignant tumors of orofacial origin in Iran. J Craniofac Surg. 2008;19(6):1538-41.

7. Mousavi SM, Gouya MM, Ramazani R, Davanlou M, Hajsadeghi N, Seddighi Z. Cancer incidence and mortality in Iran. Ann Oncol. 2009; 20(3):556-63.

8. Razavi SM, Siadat S, Rahbar P, Hosseini SM, Shirani AM. Trends in oral cancer rates in Isfahan, Iran during 1991-2010. Dent Res J (Isfahan). 2012; 9(Suppl 1):S88-S93.

9. Baharvand M, Mortazavi H. Characteristics of Hodgkin lymphoma in a defined group of Iranian pediatric patients. Asian Pac J Cancer Prev. 2014; 15(13):5167-9.

10. Basirat M, Rabiei M, Bashardoust N. Incidence of Head and Neck Lymphoma in Guilan Province, Iran. Asian Pac J Cancer Prev. 2016;17:1-4.

11. Zapater E, Bagán JV, Carbonell F, Basterra J. Malignant lymphoma of the head and neck. Oral Dis. 2010;16(2):119-28.

12. Shima N, Kobashi Y, Tsutsui K, Ogawa K, Maetani SH, Nakashima Y, et al. Extranodal non-Hodgkin's lymphoma of the head and neck. A clinicopathologic study in the Kyoto-Nara area of Japan. Cancer. 1990; 66(6):1190-7.

13. Urquhart A, Berg R. Hodgkin's and non-Hodgkin's lymphoma of the head and neck. Laryngoscope. 2001;111(9):1565-9.

14. Shamloo N, Lotfi A, Motazadian HR, Mortazavi H, Baharvand M. Squamous Cell Carcinoma as the Most Common Lesion of the Tongue in Iranians: a 22-Year Retrospective Study. Asian Pac J Cancer Prev. 2016;17(3):1415-9.

15. Huh J. Epidemiologic overview of malignant lymphoma. Korean J Hematol. 2012;47(2):92-104.

16. Epstein JB, Epstein JD, Le ND, Gorsky M. Characteristics of oral and paraoral malignant lymphoma: a population-based review of 361 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 92(5):519-25.

17. Essadi I, Ismaili N, Tazi E, Elmajjaoui S, Saidi A, Ichou M, et al. Primary lymphoma of the head and neck: two case reports and review of the literature. Cases J. 2008;1(1):426.

18. Baris D, Zahm SH. Epidemiology of lymphomas. Curr Opin Oncol. 2000;12:383–94.

19. Glaser SL, Swartz WG. Time trends in Hodgkin's disease incidence. The role of diagnostic accuracy. Cancer. 1990; 66(10):2196–2204.

20. Glaser SL. Reproductive factors in Hodgkin's disease in women: a review. Am J Epidemiol. 1994; 139:237–46.

21. Kemp S, Gallagher G, Kabani S, Noonan V, O'Hara C. Oral non-Hodgkin's lymphoma: review of the literature and World Health Organization classification with reference to 40 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 105:194-201.

22. Mani H, Jaffe ES. Hodgkin lymphoma: an update on its biology with new insights into classification. Clin Lymphoma Myeloma. 2009; 9: 206-16.

23. Jarrett RF. Viruses and Hodgkin's lymphoma. Ann Oncol. 2002;13(Suppl 1):23–9.

24. Zucca E, Roggero E, Bertoni F, Conconi A, Cavalli F. Primary extranodal non-Hodgkin's lymphomas. Part 2: Head and neck, central nervous system and other less common sites. Ann Oncol. 1999;10(9):1023-33.