Iranian Journal of Otorhinolaryngology

Iranian Journal of Otorhinolaryngology

Intratympanic Steroid for the Management of Sudden Hearing Loss: Introduction of a Tapering Method

Document Type : Original

Authors
Mohsen Rajati 1
Mohammad Mehdi Ghasemi 1
Mohammad Reza Sharifian 1
Navid Nourizadeh 1
Razieh Yousefi 2
Masoomeh Hosseinpoor 1
1 Sinus and Surgical Endoscopic Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Biostatistics, Health School, Mashhad University of Medical Sciences, Mashhad, Iran.
10.22038/ijorl.2021.57477.2977
Abstract
Introduction:
Sudden sensorineural hearing loss (SSNHL) is a therapeutic challenge. There are several controversies regarding the management protocol of SSNHL. This study aimed to present the results of a novel treatment algorithm, which is a combination of systemic steroids and a tapering intratympanic (IT) dexamethasone regimen.
Materials and Methods:
The past 10 years’ medical records of idiopathic SSNHL cases in Ghaem and Emamreza hospital, Mashhad University of Medical Sciences were evaluated. Patients were assessed using standardized methods for pure-tone threshold audiometry. The management method of SSNHL treatment included oral steroids combined with IT administration of dexamethasone once a day for 7 days and continuing it on an alternate day and then weekly basis. Patients’ recovery was assessed using Siegel’s criteria.
Results:
This study included a total of 248 cases of idiopathic sudden hearing loss, with a mean age of 40.63±16.19 years. In total, 105 (42.3%) and 143 (57.7%) patients were female and male, respectively. The most common associated symptoms included tinnitus (86.9%, n=205) followed by vertigo (52.1%, n=122). The final hearing outcome of patients showed that 39 (15.7%), 38(15.3%), 86 (34.7%), and 85 (34.3%) patients underwent a complete recovery, partial recovery, slight recovery, and no recovery, based on Siegel’s criteria.
Conclusions:
The dose, interval, and duration of IT steroid treatment were not universally approved. The treatment method designed based on a tapering of IT steroid injection in combination with already known systemic administration of steroids can be a treatment option in SSNHL patients. 
Keywords
Intratympanic
steroid
sudden sensorineural hearing loss
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Iranian Journal of Otorhinolaryngology
Volume 34, Issue 1
January and February 2022
Pages 9-16